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Article

Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression

2 May 2023

Abstract excerpt

Leukemogenesis is proposed to be a multistep process by which normal hematopoietic stem and progenitor cells are transformed into full-blown leukemic cells, the details of which are not fully understood. Here, we performed serial single-cell transcriptome analyses of preleukemic and leukemic cells (PLCs) and constructed the cellular and molecular transformation trajectory in a Myc-driven acute myeloid leukemia...

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PMID: 37130348
DOI: 10.1371/journal.pbio.3002088

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