Article

Dissecting infant leukemia developmental origins with a hemogenic gastruloid model

2022-10-07

Abstract excerpt

<h4>ABSTRACT</h4> Current in vitro models of developmental blood formation lack spatio-temporal accuracy and weakly replicate successive waves of hematopoiesis. Herein, we describe a mouse embryonic stem cell (SC)-derived 3D hemogenic gastruloid (haemGx) that captures multi-wave blood formation, progenitor specification from hemogenic endothelium (HE), and generates hematopoietic progenitors capable of short-term...

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Literature Corpus work: 92452f32-996f-5f3b-b36a-4ec784dd160b
DOI: 10.1101/2022.10.07.511362

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