The Crossroads of Clonal Evolution, Differentiation Hierarchy, and Ontogeny in Leukemia Development

Abstract excerpt

Abstract Transformative technologies to sequence tumor genomes at large scale and single-cell resolution have exposed the repertoire of genetic alterations that are present in leukemia genomes, the timing of their acquisition, and patterns of their co-occurrence. In parallel, single-cell multiomics technologies are allowing us to map the differentiation paths and hierarchical structures of malignant cells and...