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Article

Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding.

Stem cell reports - 13 Jan 2015

Klauke Karin, Broekhuis Mathilde J C, Weersing Ellen, Dethmers-Ausema Albertina, Ritsema Martha, González Marta Vilà, Zwart Erik, Bystrykh Leonid V, de Haan Gerald

Abstract excerpt

Accurate monitoring of tumor dynamics and leukemic stem cell (LSC) heterogeneity is important for the development of personalized cancer therapies. In this study, we experimentally induced distinct types of leukemia in mice by enforced expression of Cbx7. Simultaneous cellular barcoding allowed for thorough analysis of leukemias at the clonal level and revealed high and unpredictable tumor complexity. Multiple...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25434821
DOI: 10.1016/j.stemcr.2014.10.012
PMCID: PMC4297865

Genes

CBX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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