Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

doi:10.1002/emmm.201302661

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Article

Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model.

EMBO molecular medicine - 1 Dec 2013

Cabezas-Wallscheid Nina, Eichwald Victoria, de Graaf Jos, Löwer Martin, Lehr Hans-Anton, Kreft Andreas, Eshkind Leonid, Hildebrandt Andreas, Abassi Yasmin, Heck Rosario, Dehof Anna Katharina, Ohngemach Svetlana, Sprengel Rolf, Wörtge Simone, Schmitt Steffen, Lotz Johannes, Meyer Claudius, Kindler Thomas, Zhang Dong-Er, Kaina Bernd, Castle John C, Trumpp Andreas, Sahin Ugur, Bockamp Ernesto

Abstract excerpt

The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pattern of human t(8;21) CBF AML with global transcriptome sequencing, we find that disease progression was...

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PMID: 24124051
DOI: 10.1002/emmm.201302661
PMCID: PMC3914523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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