Article

Dissecting the tumorigenesis trajectory by single-cell RNA-seq reveals critical roles of RNA splicing

2022-10-03

Abstract excerpt

<h4>Background: </h4> Leukemogenesis is proposed to be a multistep process by which normal hematopoietic stem and progenitor cells are transformed into full-blown leukemic cells, the details of which are not fully understood. Methods We performed serial single-cell transcriptome analyses(10X genomics) of preleukemic and leukemic cells (PLCs) and constructed the cellular and molecular transformation trajectory in...

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Literature Corpus work: 489fd515-eb74-574f-b0b0-702f5a9641e1
DOI: 10.21203/rs.3.rs-2105579/v1

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