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Article

PHF6 suppresses self-renewal of leukemic stem cells in AML

14 Jul 2024

Abstract excerpt

Acute myeloid leukemia is characterized by uncontrolled proliferation of self-renewing myeloid progenitors accompanied by a differentiation arrest. PHF6 is a chromatin-binding protein mutated in myeloid leukemias, and its isolated loss increases mouse HSC self-renewal without malignant transformation. We report here that Phf6 knockout increases the aggressiveness of Hoxa9-driven AML over serial transplantation,...

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Share to Acute Myeloid Leukemia Research
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PMID: 39004675
DOI: 10.1038/s41375-024-02340-5

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