Article

Alternative polyadenylation mediates genetic regulation of gene expression

2019-11-17

Abstract excerpt

With the exception of mRNA splicing, little is known about co-transcriptional or post-transcriptional regulatory mechanisms that link noncoding variation to variation in organismal traits. To begin addressing this gap, we used 3’ Seq to characterize alternative polyadenylation (APA) in the nuclear and total RNA fractions of 52 HapMap Yoruba lymphoblastoid cell lines, which we have studied extensively in the past....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a9244754-c7fa-5c79-8ef1-e5f5270f354e
DOI: 10.1101/845966

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Alternative polyadenylation mediates genetic regulation of gene expressionDOI 10.1101/845966Read

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.Semantic proximity Read

Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and DiseasesSemantic proximity Read

A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association studySemantic proximity Read

Alternative polyadenylation-associated loci interpret human traits and diseases.Semantic proximity Read

Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancersSemantic proximity Read

Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes.Semantic proximity Read

DeepSAGE reveals genetic variants associated with alternative polyadenylation and expression of coding and non-coding transcripts.Semantic proximity Read

Systematic identification of functional SNPs interrupting 3’ UTR polyadenylation signalsSemantic proximity Read

RNA splicing is a primary link between genetic variation and disease.Semantic proximity Read

Systematic identification of functional SNPs interrupting 3'UTR polyadenylation signals.Semantic proximity Read

Cell-type-specific alternative polyadenylation (APA) genes reveal the function of dynamic APA in complex tissuesSemantic proximity Read

Divergence in alternative polyadenylation contributes to gene regulatory differences between humans and chimpanzeesSemantic proximity Read