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Article

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.

Nature genetics - 1 Jul 2021

Li Lei, Huang Kai-Lieh, Gao Yipeng, Cui Ya, Wang Gao, Elrod Nathan D, Li Yumei, Chen Yiling Elaine, Ji Ping, Peng Fanglue, Russell William K, Wagner Eric J, Li Wei

Abstract excerpt

Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3'UTR alternative polyadenylation (APA) quantitative trait loci (3'aQTLs), containing approximately 0.4 million common genetic variants associated with the APA of...

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PMID: 33986536
DOI: 10.1038/s41588-021-00864-5

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