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Alternative polyadenylation-associated loci interpret human traits and diseases.

Trends in genetics : TIG - 1 Sept 2021

Fang Zhixiao, Li Shengli

Abstract excerpt

Alternative polyadenylation (APA)-associated genetic variants have been proposed to impact diverse human phenotypes and disorders. In a recent study, Li et al. established a landscape of 3'-untranslated region (UTR) APA quantitative trait loci (3'aQTLs) across multiple human tissues, revealing substantial 3'aQTLs that contribute to complex human traits and diseases.

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3' Untranslated Regions
Multifactorial Inheritance
Phenotype
Polyadenylation
Quantitative Trait Loci

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PMID: 34148698
DOI: 10.1016/j.tig.2021.06.002

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