Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk Loci

5 Sept 2023

Abstract excerpt

Alternative polyadenylation (APA) is emerging as a major mechanism of posttranscriptional regulation. APA can impact the development and progression of cancer, suggesting that the genetic determinants of APA might play an important role in regulating cancer risk. Here, we depicted a pan-cancer atlas of human APA quantitative trait loci (apaQTL), containing approximately 0.7 million apaQTLs across 32 cancer types....

Source

Identifiers

PMID: 37669142
DOI: 10.1158/0008-5472.can-23-0251

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Variants That Impact Alternative Polyadenylation in Cancer Represent Candidate Causal Risk LociPMID 37669142Read ↗

Large-Scale Alternative Polyadenylation-Wide Association Studies to Identify Putative Cancer Susceptibility Genes.Semantic proximity Read ↗

Large-scale alternative polyadenylation (APA)-wide association studies to identify putative susceptibility genes in human common cancersSemantic proximity Read ↗

A distinct class of pan-cancer susceptibility genes revealed by alternative polyadenylation transcriptome-wide association studySemantic proximity Read ↗

Genetic Basis of Alternative Polyadenylation is an Emerging Molecular Phenotype for Human Traits and DiseasesSemantic proximity Read ↗

An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability.Semantic proximity Read ↗

Alternative polyadenylation quantitative trait loci contribute to acute myeloid leukemia risk genes regulation.Semantic proximity Read ↗

Alternative Polyadenylation Associated with Prognosis and Therapy in Colorectal CancerSemantic proximity Read ↗

Alternative polyadenylation-associated loci interpret human traits and diseases.Semantic proximity Read ↗

Integrating apaQTL and eQTL analysis identifies a potential causal variant associated with lung adenocarcinoma risk in the Chinese population.Semantic proximity Read ↗

Impact of Rare Non-coding Variants on Human Diseases through Alternative Polyadenylation OutliersSemantic proximity Read ↗

Characterization of Immune-Related Alternative Polyadenylation Events in Cancer ImmunotherapySemantic proximity Read ↗

Crosstalk among Alternative Polyadenylation, Genetic Variants and Ubiquitin Modification Contribute to Lung Adenocarcinoma Risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.