Article

Dense CRISPR Mapping of the WAVE Complex Identifies Pharmacological Modulators of AD-Linked Myeloid Migration

2026-07-03

Abstract excerpt

Although genetic risk for Alzheimer’s disease (AD) strongly converges on microglial pathways, the druggable functional protein regions that control disease-relevant microglial behaviors remain largely unknown. Here, we applied dense CRISPR-Cas9 mutagenesis and CRISPRtile-based functional mapping to the WAVE regulatory complex (WRC), a central regulator of actin remodeling and cell migration. In a pooled CCL2-direc...

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Literature Corpus work: 90e82a57-9fec-59ae-9f4e-ad09b46eac4e
DOI: 10.64898/2026.06.30.735672

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