Article

Single-cell gene networks nominate <i>IKZF1</i> as an Alzheimer’s microglial regulator

2026-07-15

Abstract excerpt

<h4>Background</h4> Microglia drive neuroinflammation in Alzheimer’s disease (AD), yet no approved therapy targets this compartment. Human genome-wide association studies consistently implicate innate immune loci in AD risk, establishing microglial transcriptional programs as therapeutically relevant but pharmacologically underexploited targets. <h4>Objective</h4> We sought to identify transcription factors (TFs...

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Literature Corpus work: c7f4a3cc-30f8-5bfa-bdb3-673c8df340d1
DOI: 10.64898/2026.07.14.738463

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