Article

A Multi-omic Atlas of Human Choroid Plexus in Alzheimer’s Disease

2025-11-25

Abstract excerpt

The choroid plexus (CP) regulates barrier integrity, cerebrospinal-fluid (CSF) dynamics, and immune surveillance, yet its role in Alzheimer’s disease (AD) remains poorly defined. We performed snRNA-seq on CP samples from 69 ROSMAP participants spanning normal cognition, mild cognitive impairment, and AD dementia, and integrated these data with spatial transcriptomics, snATAC-seq, and proteomics from CP tissue and...

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Literature Corpus work: b5ab78df-3d13-5cc0-97bb-3572eb5b95af
DOI: 10.1101/2025.11.23.690014

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