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Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genes

2025-07-18

Abstract excerpt

<h4>Summary</h4> Emerging research has implicated Alzheimer’s disease (AD) pathology with dysregulation of many key pathways in microglia, including lipid transport and metabolism, phagocytosis of plaques, and lysosomal function. However, the exact mechanisms underlying these pathways remain poorly understood. Leveraging high-throughput CRISPR screens to understand the interplay between these pathways may enable...

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Literature Corpus work
25f26a81-71c9-5dc4-b175-45f65105cd01
DOI
10.1101/2025.07.17.660041
Open publication

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Integrative analysis of pooled CRISPR screens provide functional insights into AD GWAS risk genesDOI 10.1101/2025.07.17.660041
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