Integrated Multi-omics Reveals MEF2C as a Direct Regulator of Microglial Immune and Synaptic Programs

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Patients with MEF2C haploinsufficiency exhibit a clinically recognizable syndrome characterized by intellectual disability, intractable seizures, and autism spectrum behaviors. Although MEF2C is well-established as a critical transcription factor in cardiac development and neuronal function, its regulatory roles in microglia—the brain’s resident immune cells—...

Topics

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• Brain Diseases
• Child, Preschool
• High-Throughput Nucleotide Sequencing
• Infant
• Inflammation
• London
• Molecular Diagnostic Techniques
• Sensitivity and Specificity

Identifiers and source

Literature Corpus work

a6d31fb7-9bad-5417-9b0d-d2c80515a3e1

DOI

10.21203/rs.3.rs-7980950/v1