Article

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screens

2026-01-09

Abstract excerpt

Immune dysfunction in cancer is enacted by multiple programs, including tumor cell-intrinsic responses to distinct immune subpopulations. A subset of these immune evasion programs can be systematically recapitulated through direct tumor-immune interactions in vitro . Here, we present an integrated, high-throughput single-cell CRISPR screening framework focused on the protein kinome for mapping the tumor-intrinsic...

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Literature Corpus work: 7df0bcd0-77f4-5728-aba3-6c4bbc6033a8
DOI: 10.64898/2026.01.08.698516

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