Article

<i>PLCG2</i> as a Risk Factor for Alzheimer’s Disease

2020-05-22

Abstract excerpt

Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Indeed, genetic variants in microglial genes are linked to risk for AD. Phospholipase C γ 2 (PLCG2) participates in the transduction of signals emanating from immune cell-surface receptors that regulate the inflammatory response and is selectively expressed by microglia in the brain. A rare...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 904f75f7-a478-56f6-8a1f-f163b3587301
DOI: 10.1101/2020.05.19.104216

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>PLCG2</i> as a Risk Factor for Alzheimer’s DiseaseDOI 10.1101/2020.05.19.104216Read

PLCG2 as a Risk Factor for Alzheimer's DiseaseSemantic proximity Read

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.Semantic proximity Read

Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s DiseaseSemantic proximity Read

PLCG2 as a Risk Factor for Alzheimer's Disease.Semantic proximity Read

PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s diseaseSemantic proximity Read

Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorphSemantic proximity Read

The Alzheimer’s disease-associated protective <i>Plcγ2</i> -P522R variant promotes beneficial microglial functionsSemantic proximity Read

PLCG2 signaling and genetic resilience in Alzheimer's disease.Semantic proximity Read

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s diseaseSemantic proximity Read

Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functionsSemantic proximity Read

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.Semantic proximity Read

Uncoupling of synaptic loss from amyloid burden by an Alzheimer’s disease protective variant of PLCγ2Semantic proximity Read