Article

Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functions

2024-09-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> PLCγ2-P522R (phospholipase C gamma 2, proline 522 to arginine) is a protective variant that reduces the risk for late onset Alzheimer’s disease. Recently, it was shown to decrease β-amyloid pathology in 5XFAD mouse model of AD. In this study, our goal was to investigate the protective functions of PLCγ2-P522R variant in a less aggressive mouse model of AD as well as to asses...

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Literature Corpus work: 1983827e-27b7-5ebf-b2b4-68410deec22f
DOI: 10.1101/2024.09.12.612207

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