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PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease

18 Feb 2022

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Accumulating evidence from genetic studies suggests the importance of phospholipase C γ 2 (PLCG2) in late-onset AD (LOAD) pathophysiology. However, the role of PLCG2 in AD is still poorly understood. METHODS: Using bulk RNA-Seq (N=1249) data from the Accelerating Medicines...

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PMID: 35180881
DOI: 10.1186/s13073-022-01022-0

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