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Article

PLCG2 signaling and genetic resilience in Alzheimer's disease.

Molecular neurodegeneration - 26 Mar 2026

Tsai Andy P, Martin Amara K, Mi Andrew, Yeh Ava E, Ramirez Lopez Eduardo, Wyss-Coray Tony

Abstract excerpt

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and pathological hallmarks, including amyloid plaques, tau tangles, microgliosis, and chronic neuroinflammation. Over the past decade, advances in human genetics have revealed microglia and the innate immune pathways are central determinants of AD susceptibility, resilience, and progression, fundamentally...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phospholipase C gamma

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Source

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Identifiers

PMID: 41888907
DOI: 10.1186/s13024-026-00935-3
PMCID: PMC13023205

Genes

PLCG2
INPP5D
TREM2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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