Article

Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph

2018-09-08

Abstract excerpt

<h4>ABSTRACT</h4> Recent Genome Wide Association Studies (GWAS) have identified novel rare coding variants in immune genes associated with late onset AD (LOAD). Amongst these, a polymorphism in Phospholipase C-gamma 2 (PLCG2) P522R, has been reported to be protective against LOAD. PLC enzymes are key elements in signal transmission networks and are potentially druggable targets. PLCG2 is highly expressed in the h...

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Literature Corpus work: e9fdd176-45c9-5901-a942-8cec4282003a
DOI: 10.1101/409706

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