Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.

doi:10.1016/j.immuni.2023.08.008

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Article

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.

Immunity - 12 Sept 2023

Tsai Andy P, Dong Chuanpeng, Lin Peter Bor-Chian, Oblak Adrian L, Viana Di Prisco Gonzalo, Wang Nian, Hajicek Nicole, Carr Adam J, Lendy Emma K, Hahn Oliver, Atkins Micaiah, Foltz Aulden G, Patel Jheel, Xu Guixiang, Moutinho Miguel, Sondek John, Zhang Qisheng, Mesecar Andrew D, Liu Yunlong, Atwood Brady K, Wyss-Coray Tony, Nho Kwangsik, Bissel Stephanie J, Lamb Bruce T, Landreth Gary E

Abstract excerpt

Genetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer's disease (AD) pathogenesis. Phospholipase C-gamma-2 (PLCG2) is selectively expressed by microglia and functions in many immune receptor signaling pathways. In AD, PLCG2 is induced uniquely in plaque-associated microglia. A genetic variant of PLCG2, PLCG2P522R, is a mild hypermorph that attenuates...

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PMID: 37659412
DOI: 10.1016/j.immuni.2023.08.008
PMCID: PMC10564391

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