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PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s disease

6 Sept 2022

Abstract excerpt

Alzheimer’s disease (AD) is an irreversible neurodegenerative disease mainly characterized by memory loss and cognitive decline. The etiology of AD is complex and remains incompletely understood. In recent years, genome-wide association studies (GWAS) have increasingly highlighted the central role of microglia in AD pathology. As a trans-membrane receptor specifically present on the microglia in the central...

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PMID: 36147734
DOI: 10.3389/fcell.2022.999061

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