Article

The Alzheimer’s disease-associated protective <i>Plcγ2</i> -P522R variant promotes beneficial microglial functions

2020-04-09

Abstract excerpt

<h4>Background</h4> Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer’s disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare coding variant in the PLCG2 gene (rs72824905, p.P522R) selectively expressed in microglia and macrophages was recently identified and shown to reduce the risk for AD....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6fee0c00-3d6d-5459-9690-c2355e5316b4
DOI: 10.1101/2020.04.08.031567

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Alzheimer’s disease-associated protective <i>Plcγ2</i> -P522R variant promotes beneficial microglial functionsDOI 10.1101/2020.04.08.031567Read

The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.Semantic proximity Read

Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functionsSemantic proximity Read

<i>PLCG2</i> as a Risk Factor for Alzheimer’s DiseaseSemantic proximity Read

The Alzheimer’s disease protective P522R variant of <i>PLCG2</i> , consistently enhances stimulus-dependent PLCγ2 activation, depleting substrate and altering cell functionSemantic proximity Read

Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s DiseaseSemantic proximity Read

Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapsesSemantic proximity Read

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer's disease.Semantic proximity Read

PLCG2 signaling and genetic resilience in Alzheimer's disease.Semantic proximity Read

Heterozygous expression of the Alzheimer’s disease protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.Semantic proximity Read

PLCγ2 impacts microglia-related effectors revealing variants and pathways important in Alzheimer’s diseaseSemantic proximity Read

Alzheimer’s disease Phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorphSemantic proximity Read

PLCG2 as a Risk Factor for Alzheimer's DiseaseSemantic proximity Read