Article

Uncoupling of synaptic loss from amyloid burden by an Alzheimer’s disease protective variant of PLCγ2

2023-09-22

Abstract excerpt

A rare coding missense variant (rs72824905; P522R) in PLCG2 decreases the risk of late-onset Alzheimer’s disease, but how this protective effect is mediated is unclear. Here we demonstrate a mechanism for this protection, the R522 variant of PLCγ2 alters microglial activity leading to a marked preservation of synaptic integrity and reduced peri-plaque microglial engulfment of synapses independently of amyloid bur...

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Literature Corpus work: 3138eded-8b46-5d5e-8a21-ebeec05e9df5
DOI: 10.1101/2023.09.22.558987

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