Article
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.
Molecular neurodegeneration - 11 Sept 2020
Takalo Mari, Wittrahm Rebekka, Wefers Benedikt, Parhizkar Samira, Jokivarsi Kimmo, Kuulasmaa Teemu, Mäkinen Petra, Martiskainen Henna, Wurst Wolfgang, Xiang Xianyuan, Marttinen Mikael, Poutiainen Pekka, Haapasalo Annakaisa, Hiltunen Mikko, Haass Christian
Abstract excerpt
BACKGROUND: Microglia-specific genetic variants are enriched in several neurodegenerative diseases, including Alzheimer's disease (AD), implicating a central role for alterations of the innate immune system in the disease etiology. A rare coding variant in the PLCG2 gene (rs72824905, p.P522R) expressed in myeloid lineage cells was recently identified and shown to reduce the risk for AD. METHODS: To assess the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.