Article

Genetic Variants of Phospholipase C-γ2 Confer Altered Microglial Phenotypes and Differential Risk for Alzheimer’s Disease

2022-12-09

Abstract excerpt

<h4>Summary</h4> Genetic association studies have demonstrated the critical involvement of the microglial immune response in Alzheimer’s disease (AD) pathogenesis. Phospholipase C-gamma-2 (PLCG2) is selectively expressed by microglia and acts in many immune receptor signaling pathways. In AD, PLCG2 is induced uniquely in plaque-associated microglia. A genetic variant of PLCG2 , PLCG2 P522R , is a mild hypermorp...

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Literature Corpus work: 58269404-6e59-5b11-a8e8-3607588ce821
DOI: 10.1101/2022.12.08.519685

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