Article

Resistance is futile: A CRISPR homing gene drive targeting a haplolethal gene

2019-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Engineered gene drives are being explored as a potential strategy for the control of vector-borne diseases due to their ability to rapidly spread genetic modifications through a population. While an effective CRISPR homing gene drive for population suppression has recently been demonstrated in mosquitoes, formation of resistance alleles that prevent Cas9 cleavage remains the major obstacle for d...

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Literature Corpus work: 90464f30-e9a1-55c2-b35c-54707563b05a
DOI: 10.1101/651737

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