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Article

A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.

Journal of genetics and genomics = Yi chuan xue bao - 1 Aug 2024

Hou Shibo, Chen Jingheng, Feng Ruobing, Xu Xuejiao, Liang Nan, Champer Jackson

Abstract excerpt

CRISPR homing gene drives have considerable potential for managing populations of medically and agriculturally significant insects. They operate by Cas9 cleavage followed by homology-directed repair, copying the drive allele to the wild-type chromosome and thus increasing in frequency and spreading throughout a population. However, resistance alleles formed by end-joining repair pose a significant obstacle. To...

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PMID: 38599514
DOI: 10.1016/j.jgg.2024.04.001

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