Article

Reducing resistance allele formation in CRISPR gene drives

2017-06-14

Abstract excerpt

<h4>ABSTRACT</h4> CRISPR gene drives can efficiently convert heterozygous cells with one copy of the drive allele into homozygotes, thereby enabling super-Mendelian inheritance. This mechanism could be used, for example, to rapidly disseminate a genetic payload through a population, promising novel strategies for the control of vector-borne diseases. However, all CRISPR gene drives tested have produced significan...

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Literature Corpus work: 184af90b-a6b7-5953-ba24-f1a47a579ca6
DOI: 10.1101/150276

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