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Gene drive-based population suppression in the malaria vector Anopheles stephensi

24 Jan 2025

Abstract excerpt

Gene drives are alleles that can bias the inheritance of specific traits in target populations for the purpose of modification or suppression. Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting the female-specific exon of doublesex, incorporating two gRNAs and a nanos-Cas9 to reduce functional resistance and improve female heterozygote fitness. Our...

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CRISPR and Genetic Engineering
Insect symbiosis and bacterial influences
Mosquito-borne diseases and control

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39856077
DOI: 10.1038/s41467-025-56290-2

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