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Article

Gene drive-based population suppression in the malaria vector Anopheles stephensi.

Nature communications - 24 Jan 2025

Xu Xuejiao, Chen Jingheng, Wang You, Liu Yiran, Zhang Yongjie, Yang Jie, Yang Xiaozhen, Chen Bin, He Zhengbo, Champer Jackson

Abstract excerpt

Gene drives are alleles that can bias the inheritance of specific traits in target populations for the purpose of modification or suppression. Here, we construct a homing suppression drive in the major urban malaria vector Anopheles stephensi targeting the female-specific exon of doublesex, incorporating two gRNAs and a nanos-Cas9 to reduce functional resistance and improve female heterozygote fitness. Our...

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PMID: 39856077
DOI: 10.1038/s41467-025-56290-2
PMCID: PMC11760374

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