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A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.

G3 (Bethesda, Md.) - 30 May 2022

Yang Emily, Metzloff Matthew, Langmüller Anna M, Xu Xuejiao, Clark Andrew G, Messer Philipp W, Champer Jackson

Abstract excerpt

Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially be used to modify or suppress pest populations, such as mosquitoes that spread diseases. CRISPR/Cas9 homing drives, which copy themselves by homology-directed repair in drive/wild-type heterozygotes, are a powerful form of gene drive, but they are vulnerable to...

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PMID: 35394026
DOI: 10.1093/g3journal/jkac081
PMCID: PMC9157102

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