Article

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles

2021-05-28

Abstract excerpt

<h4>ABSTRACT</h4> Gene drives are engineered alleles that can bias inheritance in their favor, allowing them to spread throughout a population. They could potentially be used to modify or suppress pest populations, such as mosquitoes that spread diseases. CRISPR/Cas9 homing drives, which copy themselves by homology-directed repair in drive/wild-type heterozygotes, are a powerful form of gene drive, but they are v...

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Literature Corpus work: 92f9ed5e-40df-5b0b-86e8-354550c0a4e7
DOI: 10.1101/2021.05.27.446071

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