Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 2020

Champer Jackson, Yang Emily, Lee Esther, Liu Jingxian, Clark Andrew G, Messer Philipp W

Abstract excerpt

Engineered gene drives are being explored as a new strategy in the fight against vector-borne diseases due to their potential for rapidly spreading genetic modifications through a population. However, CRISPR-based homing gene drives proposed for this purpose have faced a major obstacle in the formation of resistance alleles that prevent Cas9 cleavage. Here, we present a homing drive in Drosophila melanogaster...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR-Cas Systems
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Gene Editing

Share to Germ Cells

Share to Models, Genetic

Share to Pedigree

Share to RNA, Guide, CRISPR-Cas Systems

Source

Open in PubMed Open full text

Identifiers

PMID: 32929034
DOI: 10.1073/pnas.2004373117
PMCID: PMC7533649

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A CRISPR homing gene drive targeting a haplolethal gene removes resistance alleles and successfully spreads through a cage population.PMID 32929034Read ↗

Resistance is futile: A CRISPR homing gene drive targeting a haplolethal geneSemantic proximity Read ↗

A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance.Semantic proximity Read ↗

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance alleles.Semantic proximity Read ↗

A homing suppression gene drive with multiplexed gRNAs maintains high drive conversion efficiency and avoids functional resistance allelesSemantic proximity Read ↗

Population suppression by release of insects carrying a dominant sterile homing gene drive targeting <i>doublesex</i> in <i>Drosophila</i>Semantic proximity Read ↗

Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene driveSemantic proximity Read ↗

Double-tap gene drive uses iterative genome targeting to help overcome resistance alleles.Semantic proximity Read ↗

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAsSemantic proximity Read ↗

Reducing resistance allele formation in CRISPR gene drive.Semantic proximity Read ↗

Germline Cas9 promoters with improved performance for homing gene drive.Semantic proximity Read ↗

New germline Cas9 promoters show improved performance for homing gene driveSemantic proximity Read ↗

Population suppression by release of insects carrying a dominant sterile homing gene drive targeting doublesex in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.