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Article

Reducing resistance allele formation in CRISPR gene drive.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2018

Champer Jackson, Liu Jingxian, Oh Suh Yeon, Reeves Riona, Luthra Anisha, Oakes Nathan, Clark Andrew G, Messer Philipp W

Abstract excerpt

CRISPR homing gene drives can convert heterozygous cells with one copy of the drive allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism could be used, for example, to rapidly disseminate a genetic payload in a population, promising effective strategies for the control of vector-borne diseases. However, all CRISPR homing gene drives studied in insects thus far have produced...

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Identifiers

PMID: 29735716
DOI: 10.1073/pnas.1720354115
PMCID: PMC6003519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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