Article

Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive

2018-10-19

Abstract excerpt

<h4>ABSTRACT</h4> Gene drives could allow for control of vector-borne diseases by directly suppressing vector populations or spreading genetic payloads designed to reduce pathogen transmission. CRISPR homing gene drives work by cleaving wild-type alleles, which are then converted to drive alleles by homology-directed repair, increasing the frequency of the drive in a population. However, resistance alleles can fo...

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Literature Corpus work: 728f80e8-8ac9-5e39-b8e6-f46476825d04
DOI: 10.1101/447615

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