Article

Behavior of homing endonuclease gene drives targeting genes required for viability or female fertility with multiplexed guide RNAs

2018-03-27

Abstract excerpt

A gene drive method of particular interest for population suppression utilizes homing endonuclease genes (HEGs), wherein a site-specific nuclease-encoding cassette is copied, in the germline, into a target gene whose loss of function results in loss of viability or fertility in homozygous, but not heterozygous progeny. Earlier work in Drosophila and mosquitoes utilized HEGs consisting of Cas9 and a single gRNA th...

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Literature Corpus work: 6aedbb80-1f4b-5c49-a701-9b412430d92b
DOI: 10.1101/289546

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