Article
The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.
PLoS genetics - 1 Oct 2017
Hammond Andrew M, Kyrou Kyros, Bruttini Marco, North Ace, Galizi Roberto, Karlsson Xenia, Kranjc Nace, Carpi Francesco M, D'Aurizio Romina, Crisanti Andrea, Nolan Tony
Abstract excerpt
Gene drives have enormous potential for the control of insect populations of medical and agricultural relevance. By preferentially biasing their own inheritance, gene drives can rapidly introduce genetic traits even if these confer a negative fitness effect on the population. We have recently developed gene drives based on CRISPR nuclease constructs that are designed to disrupt key genes essential for female...
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