Article

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks

2023-12-13

Abstract excerpt

<h4>Summary</h4> In eukaryotes, CDC7 kinase is crucial for DNA replication initiation and has been involved in fork processing and replication stress response. Human CDC7 requires the binding of either one of two regulatory subunits, DBF4 and DRF1, for its activity. However, it is unclear whether the two regulatory subunits target CDC7 to a specific set of substrates, thus having different biological functions, o...

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Literature Corpus work: 8f7d540b-e50d-5dd0-8b1c-f19f36a0e44d
DOI: 10.1101/2023.12.13.568031

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