Article
Dbf4 recruitment by forkhead transcription factors defines an upstream rate-limiting step in determining origin firing timing.
Genes & development - 1 Dec 2017
Fang Dingqiang, Lengronne Armelle, Shi Di, Forey Romain, Skrzypczak Magdalena, Ginalski Krzysztof, Yan Changhui, Wang Xiaoke, Cao Qinhong, Pasero Philippe, Lou Huiqiang
Abstract excerpt
Initiation of eukaryotic chromosome replication follows a spatiotemporal program. The current model suggests that replication origins compete for a limited pool of initiation factors. However, it remains to be answered how these limiting factors are preferentially recruited to early origins. Here, we report that Dbf4 is enriched at early origins through its interaction with forkhead transcription factors Fkh1 and...
Topics
- Cell Cycle Proteins
- DNA Replication
- DNA-Binding Proteins
- Forkhead Transcription Factors
- Genome, Fungal
- Mutation
- Nuclear Proteins
- Protein Transport
- Recombinant Fusion Proteins
- Replication Origin