Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

doi:10.1074/jbc.M112.392910

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Article

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

The Journal of biological chemistry - 24 May 2013

Ramer Matthew D, Suman Evelyin S, Richter Hagen, Stanger Karen, Spranger Martina, Bieberstein Nicole, Duncker Bernard P

Abstract excerpt

The essential cell cycle target of the Dbf4/Cdc7 kinase (DDK) is the Mcm2-7 helicase complex. Although Mcm4 has been identified as the critical DDK phosphorylation target for DNA replication, it is not well understood which of the six Mcm2-7 subunits actually mediate(s) docking of this kinase complex. We systematically examined the interaction between each Mcm2-7 subunit with Dbf4 and Cdc7 through two-hybrid and...

Topics

Cell Cycle Proteins
Chromosomal Proteins, Non-Histone
DNA Replication
DNA, Fungal
DNA-Binding Proteins
Minichromosome Maintenance Complex Component 3
Minichromosome Maintenance Complex Component 4
Minichromosome Maintenance Complex Component 6
Minichromosome Maintenance Complex Component 7

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Protein Binding

Protein Serine-Threonine Kinases

Protein Structure, Tertiary

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 23549044
DOI: 10.1074/jbc.M112.392910
PMCID: PMC3663514

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Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.PMID 23549044Read ↗

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A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.Semantic proximity Read ↗

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Mcm2 phosphorylation and the response to replicative stress.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forksSemantic proximity Read ↗

Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.Semantic proximity Read ↗

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Semantic proximity Read ↗

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Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

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