Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.

The Journal of biological chemistry - 24 May 2013

Ramer Matthew D, Suman Evelyin S, Richter Hagen, Stanger Karen, Spranger Martina, Bieberstein Nicole, Duncker Bernard P

Abstract excerpt

The essential cell cycle target of the Dbf4/Cdc7 kinase (DDK) is the Mcm2-7 helicase complex. Although Mcm4 has been identified as the critical DDK phosphorylation target for DNA replication, it is not well understood which of the six Mcm2-7 subunits actually mediate(s) docking of this kinase complex. We systematically examined the interaction between each Mcm2-7 subunit with Dbf4 and Cdc7 through two-hybrid and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Fungal

Share to DNA Replication

Share to Nuclear Proteins

Share to Protein Serine-Threonine Kinases

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23549044
DOI: 10.1074/jbc.M112.392910
PMCID: PMC3663514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.PMID 23549044Read ↗

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.Semantic proximity Read ↗

A mutation in Dbf4 motif M impairs interactions with DNA replication factors and confers increased resistance to genotoxic agents.Semantic proximity Read ↗

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis.Semantic proximity Read ↗

Mcm2 phosphorylation and the response to replicative stress.Semantic proximity Read ↗

Concerted activities of Mcm4, Sld3, and Dbf4 in control of origin activation and DNA replication fork progression.Semantic proximity Read ↗

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forksSemantic proximity Read ↗

Dbf4-Cdc7 phosphorylation of Mcm2 is required for cell growth.Semantic proximity Read ↗

Mcm2-7 Is an Active Player in the DNA Replication Checkpoint Signaling Cascade via Proposed Modulation of Its DNA Gate.Semantic proximity Read ↗

Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4Semantic proximity Read ↗

Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.Semantic proximity Read ↗

Domain within the helicase subunit Mcm4 integrates multiple kinase signals to control DNA replication initiation and fork progression.Semantic proximity Read ↗

Mcm10 and the MCM2-7 complex interact to initiate DNA synthesis and to release replication factors from origins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.