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Article

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.

Molecular cell - 12 Nov 2010

Randell John C W, Fan Andy, Chan Clara, Francis Laura I, Heller Ryan C, Galani Kyriaki, Bell Stephen P

Abstract excerpt

Activation of the eukaryotic replicative DNA helicase, the Mcm2-7 complex, requires phosphorylation by Cdc7/Dbf4 (Dbf4-dependent kinase or DDK), which, in turn, depends on prior phosphorylation of Mcm2-7 by an unknown kinase (or kinases). We identified DDK phosphorylation sites on Mcm4 and Mcm6 and found that phosphorylation of either subunit suffices for cell proliferation. Importantly, prior phosphorylation of...

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Source

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Identifiers

PMID: 21070963
DOI: 10.1016/j.molcel.2010.10.017
PMCID: PMC3021128

Genes

MRC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7.PMID 21070963Read ↗

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