Article

CDC7 and CDK8 kinases cooperate to support DNA replication origin firing in human cells

2025-12-09

Abstract excerpt

The coordinated activation of DNA replication origins is important for efficient DNA synthesis and genome stability. S-phase cyclin dependent kinases (CDKs) together with CDC7 kinase, are essential to origin activation by converting the pre-replicative complex into a fully active helicase. To identify genes that tune DNA replication, we have performed a chemo-genetic genome-wide CRISPR-KO screen with cells challen...

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Literature Corpus work: 4d3936ad-e6bc-519e-88fd-3bb3d5600945
DOI: 10.64898/2025.12.09.692982

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