Article

Cdt1 variants reveal unanticipated aspects of interactions with Cyclin/CDK and MCM important for normal genome replication

2018-04-05

Abstract excerpt

<h4>ABSTRACT</h4> The earliest step in DNA replication is origin licensing which is the DNA loading of MCM helicase complexes. The Cdt1 protein is essential for MCM loading during G1 phase of the cell cycle, yet the mechanism of Cdt1 function is still incompletely understood. We examined a collection of rare Cdt1 variants that cause a form of primordial dwarfism (Meier-Gorlin syndrome) plus one hypomorphic Droso...

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Literature Corpus work: 1ad2db0e-18b2-5e50-afcb-a1753829a732
DOI: 10.1101/295212

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