Article

MYBL2 regulates ATM to control replication initiation and prevent replication stress in pluripotent stem cells

2020-06-05

Abstract excerpt

<h4>Summary</h4> Replication stress, a major cause of genome instability in cycling cells, is mainly prevented by the ATR-dependent replication stress response pathway in somatic cells. However, the replication stress response pathway in embryonic stem cells (ESCs) may be substantially different due to alterations in cell cycle phase length. The transcription factor MYBL2, which is implicated in cell cycle regula...

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Literature Corpus work: a76a345e-35d3-5d39-a1ef-c6e8b75f5f1f
DOI: 10.1101/2020.06.04.131276

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