Article

MRE11-RAD50-NBS1 activates Fanconi Anemia R-loop suppression at transcription-replication conflicts

2018-11-17

Abstract excerpt

<h4>SUMMARY</h4> Ectopic R-loop accumulation causes DNA replication stress and genome instability. To avoid these outcomes, cells possess a range of anti-R-loop mechanisms, including RNaseH that degrades the RNA moiety in R-loops. To comprehensively identify anti-R-loop mechanisms, we performed a genome-wide trigenic interaction screen in yeast lacking RNH1 and RNH201 . We identified >100 genes critical for fit...

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Literature Corpus work: 781db14e-ccdc-575d-8ee0-7418723084f9
DOI: 10.1101/472654

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