Article

Substantial somatic genomic variation and selection for <i>BCOR</i> mutations in human induced pluripotent stem cells

2021-02-04

Abstract excerpt

<h4>Summary</h4> Human Induced Pluripotent Stem Cells (hiPSC) are an established patient-specific model system where opportunities are emerging for cell-based therapies. We contrast hiPSCs derived from different tissues, skin and blood, in the same individual. We show extensive single-nucleotide mutagenesis in all hiPSC lines, although fibroblast-derived hiPSCs (F-hiPSCs) are particularly heavily mutagenized by u...

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Literature Corpus work: 8e64ff36-e1a5-537d-964e-79290b5e5b20
DOI: 10.1101/2021.02.04.429731

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