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Comprehensive assessment of the genomic stability of human induced pluripotent stem cells for clinical applications.

Stem cell research & therapy - 25 Mar 2026

Zhang Kehua, Na Tao, Jia Chuncui, Yuan Xianghe, Guo Meichen, Yang Xu, Li Min, Jia Wenwen, Bai Zhihui, Lu Jizhen, Liu Zhongmin, Meng Shufang

Abstract excerpt

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) may acquire genomic alterations during reprogramming and culture, which poses significant risks for clinical applications. Current detection methods, such as karyotyping analysis, often fail to identify critical submicroscopic variations. This highlights an urgent need for comprehensive genomic surveillance strategies. METHODS: Three human iPSC lines were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41877289
DOI: 10.1186/s13287-026-04975-w
PMCID: PMC13137665

Genes

BCL2L1
BCOR
CDH1
KRAS
MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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