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Comprehensive Assessment of the Genomic Stability of Human Induced Pluripotent Stem Cells for Clinical Applications

2025-10-14

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<title>Abstract</title> Background Human induced pluripotent stem cells (hiPSCs) acquire genomic instability during reprogramming and culture, which poses significant risks for clinical applications. Current detection methods, such as karyotyping analysis, often fail to identify critical submicroscopic variations. This highlights an urgent need for comprehensive genomic surveillance strategies. Methods Three...

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Literature Corpus work: b5330234-b4e4-5e09-b11e-f18cda6afff5
DOI: 10.21203/rs.3.rs-7522863/v1

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